Interactions between Clozapine and Codeine – Available on

for Interactions between Clozapine and Codeine - Available on

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Drugs Listing

This report displays the potential drug interactions for the following 2 drugs:

  • clozapine
  • codeine
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    Interactions between Your Drugs

    Using narcotic pain or cough medications together with other medications that also cause central nervous system depression such as cloZAPine can lead to serious side effects including respiratory distress, coma, and even death. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Do not drink alcohol or self-medicate with these medications without your doctor’s approval, and do not exceed the doses or frequency and duration of use prescribed by your doctor. Also, because these medications may cause dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed and motor coordination, you should avoid driving or operating hazardous machinery until you know how they affect you. Using narcotic pain or cough medications together with cloZAPine may also increase the risk of constipation. Severe complications may include intestinal obstruction, fecal impaction, or other serious and even life-threatening injuries to the bowel that may require hospitalization or surgery. You should maintain adequate hydration, physical activity, and fiber intake during treatment with these medications to help prevent constipation. Talk to your healthcare provider to see if taking a laxative prophylactically may be appropriate for you. Seek immediate medical attention if you experience signs and symptoms of constipation such as difficulty passing stool, incomplete passage of stool, hard or dry stool, and decreased bowel movement frequency (especially if less than three times a week), or if you have symptoms that could indicate more serious gastrointestinal problems such as nausea, vomiting, bloating, and abdominal pain or swelling. Prompt treatment with appropriate laxatives and other measures are essential to minimize the risk of complications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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    Drug and Food Interactions

    Alcohol can increase the nervous system side effects of cloZAPine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with cloZAPine. Do not use more than the recommended dose of cloZAPine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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    Therapeutic Duplication Warnings

    No warnings were found for your selected drugs. Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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    • Drug Interaction Classification

      These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

      • Major – Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
      • Moderate – Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
      • Minor – Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
      • Unknown – No interaction information available.
      • Further Information

        Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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